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Life Science Data
Manager

Catalog, curate, search Life Science Data at scale.

Big data needs better digital health. ODM makes it easy to integrate, harmonize and search Life Science Data from multiple sources making it findable, accessible, interoperable and reusable.

A collaborative data ecosystem
Alexey Dubovenko, ODM Senior Product Manager

A collaborative data ecosystem

We have specific APIs and GUI for different user classes, such as data managers, bioinformaticians and discovery scientists, so that everybody can harness the power of Life Science Data in their day to day work.”

Alexey Dubovenko, ODM Senior Product Manager

ODM IN NUMBERS

10 000+

public studies imported from 5 sources

1 000 000

indexed variants queried per minute

500 TB

of Life Science Data customers have put in their ODM instances
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Data catalog: аll your Life Science Data in one place

Record study, samples, data files and associated metadata for multiple types of omics. Never lose a dataset again.

Curation tools: generate and maintain high-quality datasets

Validate and harmonize your metadata across studies, ensure it’s complete and conforms to your data model, and power AI / ML.

Analytical search: increase data discoverability and liquidity

Perform large-scale, cross-study, and integrative queries across Life Science Data via well-documented REST APIs.

ODM at a glance

Catalog
Analytical
search
Curation
Efficient data mining

The catalog GUI gives you an overview of the scope of all data in the system (e.g. volume, omics type, common sample descriptors).

Driven by data model & curation tools

The universal data model + curation tools enable integrated cross-omics, cross-study queries, via API driven analytical search.

High-quality data at your fingertips

Powerful curation tools enable excellent findability of data (both via catalog GUI, and via API-driven analytical search) thanks to standardization by adopting a metadata model and common vocabulary.

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Seamless fit with existing IT landscapes

Your questions answered

  • What type of data does ODM support?
    • Genestack ODM is designed to be agnostic to data types. By default it supports genomics and transcriptomics, with support for proteomics coming soon, but it can easily be adapted to almost any type of data, whether that’s imaging, flow-cytometry data, or others.

  • What exactly do you mean by “multi-omics”?
    • “Omics” is the shorthand for many system-wide investigations in biology.  Genomics is the study of genomic information, for example genetic variation at specific locations in the genome between individuals. Transcriptomics is the study of which genes are transcribed/expressed and at what level. Proteomics aims to identify and/or quantify the proteins that are present in a sample.  By “multi-omics”, we refer to the capability of making cross-study, cross-omics queries across all your data in ODM, e.g. find studies with human samples from adult females over 30 years of age which have HER2 gene expression and have mutation detected at amino acid position 438 in the BRCA1 gene”. Such queries are possible because ODM indexes not only metadata (e.g. sample information) but also data (e.g. the expression level of a particular gene in each sample of a study).

  • How can my organization try ODM?
    • Get in touch to request a demo via our website. A member of our team will get back to you within two business days.

  • Does ODM work like an electronic lab notebook (ELN)?
    • No. ELNs are designed to replace traditional pen-and-paper lab notebooks in capturing all the text and images associated with conducting an experiment. The focus is on the researcher’s point of view and how to reproduce a methodology. Records in ELNs often read like work logs, protocols or diaries without the confine of any data model or the use of controlled vocabulary. In contrast, ODM has a focus on the data that is produced as a result of an experiment and an experiment’s context (the metadata). It ensures both data and metadata are curated, programmatically searchable, reusable and ready for downstream integration across an organization.

  • Does ODM integrate with ELNs?
    • Yes. ODM has built-in RESTful APIs which allow you to import (meta)data from ELNs or export (meta)data to ELNs.

  • Does ODM integrate into my organization’s existing workflows?
    • Yes. ODM can integrate at several different stages in the data production workflow. Typically it is used as the single source of truth for Life Science Data after the data has been processed from an instrument, but it can also be used prior to data generation to design studies and collect information in a controlled fashion. RESTful APIs allow simple integration of both upstream and downstream processes.

  • Does ODM allow data managers and curators to annotate metadata using ontologies?
    • Yes. ODM makes it easy for curators to annotate metadata, which can optionally be standardized using controlled vocabularies and ontologies. Data managers or admins can set up ODM templates which specify the controlled vocabulary or ontology to use for a given metadata field, for example,  “Use NCBI Taxonomy for the sample metadata field Organism”. In this case, during manual curation, NCBI Taxonomy terms will be suggested in a drop-down menu to the curator when filling in the value of Organism. Moreover, all metadata values will be validated on-the-fly against the designated controlled vocabularies or ontologies, including metadata that are programmatically  imported to or curated in ODM.

  • I am a data manager/curator. Can I use/upload my own ontology/dictionary?
    • Yes. We can either provide you with tools to do this or do it on your behalf. Plain comma-separated values (csv), obo and owl formats are supported. Out of the box, ODM is pre-loaded with the following ontologies/controlled vocabularies: NCBI Taxonomy for species, UBERON for mammalian tissues, Cell Ontology for cell types, Cellosaurus for cell lines, Disease Ontology for diseases, ChEBI for small molecules/compounds as well as common controlled vocabulary for measurement units and sex.

  • Does ODM support data visualization?
    • ODM’s APIs allow data querying and streaming for bioinformaticians or data scientists to build flexible, custom visualizations. We can help provide lightweight R-shiny and Jupyter Notebook examples, such as a simple application for gene expression look-up when a user enters a gene ID or gene symbol, or creating t-SNE plots from single-cell RNA-seq data for non-technical users.

  • Does ODM support bulk operations when curating metadata?
    • Yes. Some examples of ODM’s bulk operation are bulk replace, GUI Excel-like drag/drop, auto fill-down, and rule-based replacements via a Python script.

  • Does ODM allow data to be shared between relevant groups of users?
    • Yes, it is easy to share your studies with different groups of ODM users. Depending on the role of a user, he/she can have different privileges in the sharing process and group management.  At the most basic, ODM has non-sharing users who can only view the files shared with the group but cannot share them further. Sharing users, on the other hand, have rights to share data. Finally, within ODM your organization can have group administrators, who in addition to the rights of a sharing user, can invite or remove users and change their privileges.

  • Do I need programming skills to use ODM?
    • It depends on which level you want to use ODM. There is an intuitive GUI which allows easy searching for studies of interest and data curation without programming knowledge, while the RESTful APIs are available for users with programming skills who wish to query (meta)data and to scale up operations.

  • What privacy/user authentication controls does ODM have?
    • ODM supports several user authentication mechanisms such as (i) login and password authentication, (ii) Single Sign-On (SSO) authentication using SAML, and (iii) OAuth 2.0 authentication. ODM has built-in admin, write, and read authorisation levels, with group-based controls for each. ODM’s built-in authorization model is granular and supports most use cases. It can be synced with external permission systems, e.g. Active Directory.

  • What type of data does ODM support?
    • Genestack ODM is designed to be agnostic to data types. By default it supports genomics and transcriptomics, with support for proteomics coming soon, but it can easily be adapted to almost any type of data, whether that’s imaging, flow-cytometry data, or others.

  • What exactly do you mean by “multi-omics”?
    • “Omics” is the shorthand for many system-wide investigations in biology.  Genomics is the study of genomic information, for example genetic variation at specific locations in the genome between individuals. Transcriptomics is the study of which genes are transcribed/expressed and at what level. Proteomics aims to identify and/or quantify the proteins that are present in a sample.  By “multi-omics”, we refer to the capability of making cross-study, cross-omics queries across all your data in ODM, e.g. find studies with human samples from adult females over 30 years of age which have HER2 gene expression and have mutation detected at amino acid position 438 in the BRCA1 gene”. Such queries are possible because ODM indexes not only metadata (e.g. sample information) but also data (e.g. the expression level of a particular gene in each sample of a study).

  • How can my organization try ODM?
    • Get in touch to request a demo via our website. A member of our team will get back to you within two business days.

  • Does ODM work like an electronic lab notebook (ELN)?
    • No. ELNs are designed to replace traditional pen-and-paper lab notebooks in capturing all the text and images associated with conducting an experiment. The focus is on the researcher’s point of view and how to reproduce a methodology. Records in ELNs often read like work logs, protocols or diaries without the confine of any data model or the use of controlled vocabulary. In contrast, ODM has a focus on the data that is produced as a result of an experiment and an experiment’s context (the metadata). It ensures both data and metadata are curated, programmatically searchable, reusable and ready for downstream integration across an organization.

  • Does ODM integrate with ELNs?
    • Yes. ODM has built-in RESTful APIs which allow you to import (meta)data from ELNs or export (meta)data to ELNs.

  • Does ODM integrate into my organization’s existing workflows?
    • Yes. ODM can integrate at several different stages in the data production workflow. Typically it is used as the single source of truth for Life Science Data after the data has been processed from an instrument, but it can also be used prior to data generation to design studies and collect information in a controlled fashion. RESTful APIs allow simple integration of both upstream and downstream processes.

  • Can I run data analysis pipelines using ODM?
    • ODM is not a data analysis software per se. However, you can export data programmatically via ODM’s API for analysis by third party/external analysis pipelines with great flexibility. In addition, ODM plays a key role in making your organization’s data analysis-ready by making it FAIR (findable, accessible, interoperable, reusable) and liquid i.e. readily consumable data by AI/ML tools without further wrangling.

  • Does ODM support data visualization?
    • ODM’s APIs allow data querying and streaming for bioinformaticians or data scientists to build flexible, custom visualizations. We can help provide lightweight R-shiny and Jupyter Notebook examples, such as a simple application for gene expression look-up when a user enters a gene ID or gene symbol, or creating t-SNE plots from single-cell RNA-seq data for non-technical users.

  • Does ODM allow data to be shared between relevant groups of users?
    • Yes, it is easy to share your studies with different groups of ODM users. Depending on the role of a user, he/she can have different privileges in the sharing process and group management.  At the most basic, ODM has non-sharing users who can only view the files shared with the group but cannot share them further. Sharing users, on the other hand, have rights to share data. Finally, within ODM your organization can have group administrators, who in addition to the rights of a sharing user, can invite or remove users and change their privileges.

  • Do I need programming skills to use ODM?
    • It depends on which level you want to use ODM. There is an intuitive GUI which allows easy searching for studies of interest and data curation without programming knowledge, while the RESTful APIs are available for users with programming skills who wish to query (meta)data and to scale up operations.

  • What are the minimum system requirements to run ODM?
    • Although recommended requirements depend on the amount of an organization’s data assets, the starting minimum hardware requirements are 8 CPU cores and 64GB RAM*, with no special network requirements. Deployment can be on  the cloud (Saas and VPC) and/or on-prem.

  • What does the process of deploying ODM in my company look like?
    • Firstly, our team will assess your organization’s needs and goals, and give you a demo of ODM. Our scientists and developers will then work with you to map your use cases and to identify the best configuration/customization of ODM for your organization. This is followed by a Proof of Concept (PoC) project - fully supported with training workshops - where your teams will be able to try ODM hands-on, at the end of which we provide a report with a gap analysis, and recommendations on how to move forward for deployment and beyond. Finally, there will be a full deployment and scale-up, with maintenance and additional development provided on a services basis.

  • Why should my organization choose ODM over in-house?
    • We have several years of experience consulting and providing solutions in the data management space for a wide customer base, including large organizations in the pharmaceutical, consumer goods, and agriscience sectors. Genestack ODM is the result of several years of close work with a top pharmaceutical company, and it is getting adopted by top firms in other industry sectors. By choosing ODM your organization will benefit from both our scientific and software development expertise, and our experience in the data management field. This brings your organization efficiency savings and expert advice on best practises in data management. In addition, Genestack ODM is modular and future-extensible, saving the cost of in-house softwares being too monolithic and hard to extend/maintain for new data types.

  • How can my organization try ODM?
    • Get in touch to request a demo via our website. A member of our team will get back to you within two business days.

  • Does ODM integrate with ELNs?
    • Yes. ODM has built-in RESTful APIs which allow you to import (meta)data from ELNs or export (meta)data to ELNs.

  • Does ODM integrate into my organization’s existing workflows?
    • Yes. ODM can integrate at several different stages in the data production workflow. Typically it is used as the single source of truth for Life Science Data after the data has been processed from an instrument, but it can also be used prior to data generation to design studies and collect information in a controlled fashion. RESTful APIs allow simple integration of both upstream and downstream processes.

  • Does ODM allow data to be shared between relevant groups of users?
    • Yes, it is easy to share your studies with different groups of ODM users. Depending on the role of a user, he/she can have different privileges in the sharing process and group management.  At the most basic, ODM has non-sharing users who can only view the files shared with the group but cannot share them further. Sharing users, on the other hand, have rights to share data. Finally, within ODM your organization can have group administrators, who in addition to the rights of a sharing user, can invite or remove users and change their privileges.

  • How secure is ODM?
    • We take security very seriously and are ISO 27001 compliant.

      ISO 27001 is one of the most widely recognized and internationally accepted information security standards. It identifies requirements for a comprehensive Information Security Management System (ISMS), and defines how organisations should manage and handle information in a secure manner, including appropriate security controls.

      In order to achieve the certification, Genestack’s compliance was validated by an independent security firm after demonstrating an ongoing and systematic approach to managing and protecting company and customer data.

  • What privacy/user authentication controls does ODM have?
    • ODM supports several user authentication mechanisms such as (i) login and password authentication, (ii) Single Sign-On (SSO) authentication using SAML, and (iii) OAuth 2.0 authentication. ODM has built-in admin, write, and read authorisation levels, with group-based controls for each. ODM’s built-in authorization model is granular and supports most use cases. It can be synced with external permission systems, e.g. Active Directory.

  • What does the process of deploying ODM in my company look like?
    • Firstly, our team will assess your organization’s needs and goals, and give you a demo of ODM. Our scientists and developers will then work with you to map your use cases and to identify the best configuration/customization of ODM for your organization. This is followed by a Proof of Concept (PoC) project - fully supported with training workshops - where your teams will be able to try ODM hands-on, at the end of which we provide a report with a gap analysis, and recommendations on how to move forward for deployment and beyond. Finally, there will be a full deployment and scale-up, with maintenance and additional development provided on a services basis.

  • Why does my organization need Genestack ODM (ODM)?
    • Genestack ODM is an enterprise software solution that allows organizations to catalog their data, ensure the metadata is accurate and conforms to a data model, and query their (meta)data via APIs for downstream integration with analysis pipelines and/or visualization tools. Through these functionalities Genestack ODM is expected to unleash the full potential of all the data collected by making it easy to find, access, interoperate and reuse - being aligned with FAIR principles. This is important because R&D and clinical trials in the life-science sector and beyond are increasingly becoming data-intensive: many pharmaceutical, agri-science, consumer goods, and healthcare organizations have accumulated a lot of heterogeneous, un-standardized legacy data scattered in disparate sources, with obscure permissions/access rights. ODM offers a scalable solution that ensures data liquidity — that data are readily consumable by popular data science or ML/AI tools without requiring further wrangling, speeding up data-driven business decision-making processes.

  • What is the cost of not using ODM?
    • It’s becoming increasingly clear that not having systems and best practices for data management in place is a cost to organizations in many sectors, ranging from pharmaceutical, to agri-science, healthcare and consumer goods. Whilst it’s difficult to put a figure against these costs for individual organizations, a recent EU report estimates that not having FAIR research data is costing the European economy in excess of €26 bn/yr for time spent, cost of storage, licence costs, research retraction, double funding, impact on research quality, economic turnover, and machine readability of research data.

  • Why should my organization choose ODM over in-house?
    • We have several years of experience consulting and providing solutions in the data management space for a wide customer base, including large organizations in the pharmaceutical, consumer goods, and agriscience sectors. Genestack ODM is the result of several years of close work with a top pharmaceutical company, and it is getting adopted by top firms in other industry sectors. By choosing ODM your organization will benefit from both our scientific and software development expertise, and our experience in the data management field. This brings your organization efficiency savings and expert advice on best practises in data management. In addition, Genestack ODM is modular and future-extensible, saving the cost of in-house softwares being too monolithic and hard to extend/maintain for new data types.

  • How can my organization try ODM?
    • Get in touch to request a demo via our website. A member of our team will get back to you within two business days.

  • Does ODM integrate into my organization’s existing workflows?
    • Yes. ODM can integrate at several different stages in the data production workflow. Typically it is used as the single source of truth for Life Science Data after the data has been processed from an instrument, but it can also be used prior to data generation to design studies and collect information in a controlled fashion. RESTful APIs allow simple integration of both upstream and downstream processes.

  • As an organisation, do we need to change the way we work to use ODM?
    • Perhaps, but in a good way. ODM allows your organisation to build a FAIR compliant eco-system - it can be at the centre of your FAIRification efforts, or it can plug-in to your existing workflows. While the amount of change ultimately is up to each individual organisation some cultural and strategic changes are generally advised in the context of any R&D digital transformation efforts. For example:.

      (1) data must be seen as a common asset of the organisation and expected to be reused, instead of belonging to individual research groups for one-off investigations and analysis;

      (2) the organisation will need to have a data management strategy if it doesn't have one already;

      (3) the data model needs to be agreed and adhered to by all users;

      (4) dedicated administrators or data managers should be appointed or hired to enforce organisation-wide data policy and to safeguard data integrity.

  • How secure is ODM?
    • We take security very seriously and are ISO 27001 compliant.

      ISO 27001 is one of the most widely recognized and internationally accepted information security standards. It identifies requirements for a comprehensive Information Security Management System (ISMS), and defines how organisations should manage and handle information in a secure manner, including appropriate security controls.

      In order to achieve the certification, Genestack’s compliance was validated by an independent security firm after demonstrating an ongoing and systematic approach to managing and protecting company and customer data.

  • Does ODM meet FDA or other clinical regulatory compliance?
    • Genestack develops its Genestack ODM product through establishing requirements that have been cross-referenced and aligned to 21CFR Part 11, ICH Guideline for good clinical practice E6 (R2) and ISO 27002 information security controls.

      These requirements are a primary input to the design and development of Genestack ODM and enable our clients to comply with the applicable regulatory requirements during the use of the product.

      Genestack ODM is GCP compliant.